Episode 10: Dr. David Sinclair – Why We Age and Why We Don’t Have To

I'm Dr. Stephanie

My life's passion and mission is blending modern science with ancient wisdom to empower women's health and healing.

hey there

Episode 010 Dr. David Sinclair – Why We Age and Why We Don’t Have To

Harvard Medical School professor, genetics expert, and author Dr. David Sinclair joins the podcast to share his expertise on the subject of molecular genetics and the biology of aging. In this episode, Dr. Stephanie and Dr. David break down the impact that sirtuins and NAD+ have on our longevity. According to Dr. David, aging is twenty percent genetics and eighty percent lifestyle. Thus, the secret to anti-aging can be found in how we choose to live. Dr. Stephanie and Dr. David discuss the epigenetic clock, hormesis, and the benefits of resveratrol. Finally, Dr. David analyzes Horvath’s Clock and speaks to the importance of measuring age accurately.


00:52 – Introducing today’s guest, David Sinclair

06:28 – David’s origin story

08:38 – Why we age

11:17 – The genome and epigenome

13:00 – The piano metaphor

15:51 – Sirtuins explained

21:59 – Other environmental stressors that sirtuins detect

25:11 – Hormesis defined

28:13 – How NAD+ and its precursors combat aging

35:11 – Dr. Stephanie brings up a specific story from Dr. David’s book

38:40 – Friedreich’s Ataxia

39:27 – Benefits of resveratrol

45:11 – Horvath’s Clock and measuring age accurately

47:58 – The backup copy of the epigenome

53:44 – Anti-aging technologies on the horizon

55:07 – Other anti-aging best practices

56:47 – Dr. Stephanie suggests a new sequel to the Avengers franchise

57:48 – Dr. Stephanie thanks Dr. David for joining the show

58:21 – Dr. David shares with the audience where they can find the cheat sheet in his book

58:48 – Where listeners can follow Dr. David

1:00:00 – Where listeners can follow Dr. Stephanie and subscribe to her newsletter


“I wrote the book because there’s a lot of really interesting technology and things people can do in their daily lives, I believe, to live significantly longer and healthier. But, I also wanted to start the conversation because I felt no one was really saying the kinds of things that I was saying.” (08:15)

“I think that the major driver of aging, put simply, is a loss of information.” (10:19)

“I think it’s worth clarifying that the sirtuins are protectors of our bodies, but they can also cause aging by being distracted too much.” (25:11)

“It’s all about being uncomfortable. Our bodies would much rather sit in a chair and eat popcorn. There’s a whole industry based on that.” (26:19)

“I like to joke that scientists like to fight because the stakes are so low.” (42:41)

“We can predict, very accurately, how old someone is biologically. And that’s not so much related to birthday candles. It’s more about how you’ve lived your life. Twenty percent of your age will be genetic and eighty percent will be how you’ve lived.” (46:59)

“What I don’t know is how to bring people back from the dead, but I think we’re getting close to being able to keep people alive in a healthy way for much longer.” (57:31)


Better! Website

Dr. Stephanie’s Website

Dr. Stephanie’s Twitter – @dr_stephanie

Dr. Stephanie’s Instagram – @dr.stephanie.estima

Dr. Stephanie on LinkedIn

Dr. David’s Book – Lifespan: Why We Age―and Why We Don’t Have To

Dr. David’s Website

Dr. David’s Instagram – @davidsinclairphd

Dr. David’s Twitter – @davidasinclair

Dr. David’s Facebook


In animal models, more NAD is better

At least when it is paired with exercise

The Mathematical Theory Of Aging

The Horvath Clock

Reversal Of Aging & Cellular Reprogramming

Resveratrol effects 1 

Resveratrol effects 2

NMN & lifespan in mice

David’s Newsletter

David’s book


Please Subscribe to Better! With Dr. Stephanie

Join our Private Facebook Community for Better!

Rate and Review: Show your support and help spread the word by writing a review, along with a 5-star rating on Apple Podcasts: https://bettershow.co/apple


Podcast production and marketing provided by FullCast


  • Dr. David Sinclair
  • Dr. Stephanie Estima

OUR Sponsors:

Athletic Greens - An exclusive offer for the listeners of the Better! Podcast 

Orion Red Light Therapy - get 10% Off your order with Promo Code “STEPHANIE10”

Lumen - get 25% Off your order with Promo Code “DRSTEPHANIE25”

LMNT Electrolytes - A FREE 7-flavour sample pack!

you're in the right place.

Redeem Now >>

Redeem Now >>

Redeem Now >>

Redeem Now >>

PRIMEADINE - get 10% Off your order with Promo Code “DRSTEPHANIE10”

Redeem Now >>

LMNT Electrolytes - A FREE 7-flavour sample pack!

Redeem Now >>

Bioptimizer - get 10% Off your order with Promo Code “ESTIMA”

Redeem Now >>