Episode 010 Dr. David Sinclair – Why We Age and Why We Don’t Have To
Harvard Medical School professor, genetics expert, and author Dr. David Sinclair joins the podcast to share his expertise on the subject of molecular genetics and the biology of aging. In this episode, Dr. Stephanie and Dr. David break down the impact that sirtuins and NAD+ have on our longevity. According to Dr. David, aging is twenty percent genetics and eighty percent lifestyle. Thus, the secret to anti-aging can be found in how we choose to live. Dr. Stephanie and Dr. David discuss the epigenetic clock, hormesis, and the benefits of resveratrol. Finally, Dr. David analyzes Horvath’s Clock and speaks to the importance of measuring age accurately.
EPISODE NOTES
00:52 – Introducing today’s guest, David Sinclair
06:28 – David’s origin story
08:38 – Why we age
11:17 – The genome and epigenome
13:00 – The piano metaphor
15:51 – Sirtuins explained
21:59 – Other environmental stressors that sirtuins detect
25:11 – Hormesis defined
28:13 – How NAD+ and its precursors combat aging
35:11 – Dr. Stephanie brings up a specific story from Dr. David’s book
38:40 – Friedreich’s Ataxia
39:27 – Benefits of resveratrol
45:11 – Horvath’s Clock and measuring age accurately
47:58 – The backup copy of the epigenome
53:44 – Anti-aging technologies on the horizon
55:07 – Other anti-aging best practices
56:47 – Dr. Stephanie suggests a new sequel to the Avengers franchise
57:48 – Dr. Stephanie thanks Dr. David for joining the show
58:21 – Dr. David shares with the audience where they can find the cheat sheet in his book
58:48 – Where listeners can follow Dr. David
1:00:00 – Where listeners can follow Dr. Stephanie and subscribe to her newsletter
TWEETABLE QUOTES
“I wrote the book because there’s a lot of really interesting technology and things people can do in their daily lives, I believe, to live significantly longer and healthier. But, I also wanted to start the conversation because I felt no one was really saying the kinds of things that I was saying.” (08:15)
“I think that the major driver of aging, put simply, is a loss of information.” (10:19)
“I think it’s worth clarifying that the sirtuins are protectors of our bodies, but they can also cause aging by being distracted too much.” (25:11)
“It’s all about being uncomfortable. Our bodies would much rather sit in a chair and eat popcorn. There’s a whole industry based on that.” (26:19)
“I like to joke that scientists like to fight because the stakes are so low.” (42:41)
“We can predict, very accurately, how old someone is biologically. And that’s not so much related to birthday candles. It’s more about how you’ve lived your life. Twenty percent of your age will be genetic and eighty percent will be how you’ve lived.” (46:59)
“What I don’t know is how to bring people back from the dead, but I think we’re getting close to being able to keep people alive in a healthy way for much longer.” (57:31)
LINKS MENTIONED
Dr. Stephanie’s Twitter – @dr_stephanie
Dr. Stephanie’s Instagram – @dr.stephanie.estima
Dr. David’s Book – Lifespan: Why We Age―and Why We Don’t Have To
Dr. David’s Instagram – @davidsinclairphd
Dr. David’s Twitter – @davidasinclair
ADDITIONAL RESOURCES FOR THIS PODCAST
In animal models, more NAD is better
At least when it is paired with exercise
The Mathematical Theory Of Aging
Reversal Of Aging & Cellular Reprogramming
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CONTRIBUTORS
- Dr. David Sinclair
- Dr. Stephanie Estima
