Metabolic Effects of Uric Acid, Fructose, and Salt with Dr. David Perlmutter

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My life's passion and mission is blending modern science with ancient wisdom to empower women's health and healing.

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Dr. Stephanie and Dr. David Perlmutter, a board-certified neurologist and 5X NYT best-selling author discuss the new understanding of Uric Acid in the context of gout, arthritis, purines, the way that we get gout through the consumption of sugar and fructose in particular. Dr. Perlmutter reveals the metabolism of fructose and why it’s so insanely addictive. We go over the evolutionary selective bias and the reason why we burn fat vs storing fat. You’ll understand the Sodium Paradox, Serum Osmolality, and their relation to Uric Acid. Of course, we’ll discuss how the ketogenic diet affects your levels of Uric Acid and how keto cycling can help. You’ll get our proven dietary and lifestyle hacks to lower uric acid, find out the ideal Uric Acid range you should fit within, and how specific medications and alcohol are affecting your body.

Episode Overview:  

  • 1:15 Introduction
  • 4:55 Welcoming David
  • 6:19 New Understanding Uric Acid
  • 10:00 Purines and Fructose
  • 16:00 Metabolism Of Fructose And Why It’s Addicting
  • 24:25 Evolutionary Selective Bias
  • 37:04 The Reason Why We Burn Fat Vs. Storing Fat
  • 43:44 The Sodium Paradox, Serum Osmolality And Uric Acid
  • 58:14 Ketogenic Diet and Uric Acid
  • 1:01:16 Keto Cycling
  • 1:05:52 Dietary and Lifestyle Interventions To Lower Uric Acid
  • 1:15:34 Alcohol and Obesity
  • 1:19:10 Medication That Increases Uric Acid
  • 1:22:00 The Ideal Uric Acid Range
  • 1:26:00 Conclusion

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